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Kinetics of Hydrolysis of Acetylsalicylic Acid, Aspirin

Posted on Apr 14 2006 by Paul Prenzler, Dan Bedgood

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In this experiment, students examine the hydrolysis of aspirin, acetylsalicylic acid, under different conditions.  The hydrolysis of aspirin occurs much more rapidly in basic conditions, a fact which is illustrative of an important principle in pharmacology.  That is, the stability of drugs and their mechanisms of action can be strongly dependent on the pH conditions of the body system in which they operate.  This experiment includes a quantitative kinetic study of the hydrolysis of aspirin under basic conditions.

Hydrolysis of aspirin under basic conditions

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